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The Science of the Edible Hangover: Dr. Mark Scialdone Explains

Released
July 24, 2026
Runtime
2:22:30
Views
1,011 views on YouTube as of October 30, 2026
Watch on YouTube Open in The Crates

Liner notes

This week we ask the ancient old question why am I so ruined the next day after I eat edibles? Nobody better to ask than Dr. Mark with an S that is Dr. Mark Scialdone @mbesau for those who need clarification. The go to guy for organic Chemistry and even more for Canna Related info in chemistry. This question arose last week when I partook in some of @numbnuts Latest product a pistachio version of their latest product known as “SLEEP” a 180 mg per Tbsp THC/CBD/CBN Peanut Butter that let me know the next morning. We will get down to the science behind that and many other rabbit holes. You never know Dr Mark has been known to wield an axe as seen on this almost lost photo of him opening up at Woodstock so if we are lucky he might bust that out for a ADS serenade. We will also be unboxing a brand new beaker bong from @gramglass.labs with heavy walked boron, built in screens and ice catchers you can tell that functionality is most important to this company. Dave noticed them online and since we got our @cleantorch a couple weeks ago this seems like the perfect match Join us for a power sesh as we break in the beaker on the show. So get that @puffco charged your @jerome_baker bong Clean with some ice 🧊 for good measure that @zoorastore Rivo packed and grab some Yo-Tips from @yoproductsllc and get ready to rock for another edition Chapters 00:00 - Tonight on the Adam Dunn Show 01:10 - Adam’s Solo Studio Vibes & "Instagram" Weed 03:15 - Graham Glass Unboxing: The 90s Heavy Wall Style 05:10 - Public Service Announcement: Heat Your Screens! 11:45 - Rest in Peace John C. Dvorak: Dissecting the News 17:40 - The Numb Nuts "Overload" Story 21:20 - The History of Numbnuts & Early Boulder Extraction 26:30 - Dr. Mark Scialdone Joins: Chemist vs. Physician 30:35 - Throwback: Adam 12 Years Ago (The Beard Bong) 34:45 - Cannabis Beverages & The Emulsion Revolution 37:20 - Hemp Pockets vs. DEA Hearings: The Industry Split 45:00 - Edible Science: CB1 vs. CB2 Receptors 48:02 - 11-Hydroxy-THC: Why Edibles Feel 10x Stronger 55:20 - Fast-Acting Tech: How Nano-Emulsions Change Gummies 1:03:00 - The "System Check": Explaining the Edible Hangover 1:10:00 - Mushroom Adaptogens & Long-Term Storage Science 1:19:15 - The DuPont Connection: Cannabis History & Chemistry 1:22:30 - Chat Q&A: Can You Make Nano-Emulsions at Home? 1:31:00 - Kitchen Chemistry: Using Chickpea Water & Lecithin 1:42:00 - Curing Science: Terpene Desiccation & Hashishene 1:50:10 - Does It Wash? Why "Greasy" Strains are Disappearing 2:00:00 - New Tech Recap: Puffco, Zooray & Clean Torch 2:10:45 - Traveling with Cannabis: The Med Card Debate #AdamDunnShow #DrMarkScialdone #CannabisChemistry #EdibleScience #Numbnuts #GrahamGlass #NanoEmulsion #CannabisHistory #11HydroxyTHC #DunnDeal #seedsherenow #sagemastaselect #buildasoil #puffco #drmarkwithaS

Chapters

  1. [00:00] Tonight on the Adam Dunn Show
  2. [01:10] Adam’s Solo Studio Vibes & "Instagram" Weed
  3. [03:15] Graham Glass Unboxing: The 90s Heavy Wall Style
  4. [05:10] Public Service Announcement: Heat Your Screens!
  5. [11:45] Rest in Peace John C. Dvorak: Dissecting the News
  6. [17:40] The Numb Nuts "Overload" Story
  7. [21:20] The History of Numbnuts & Early Boulder Extraction
  8. [26:30] Dr. Mark Scialdone Joins: Chemist vs. Physician
  9. [30:35] Throwback: Adam 12 Years Ago (The Beard Bong)
  10. [34:45] Cannabis Beverages & The Emulsion Revolution
  11. [37:20] Hemp Pockets vs. DEA Hearings: The Industry Split
  12. [45:00] Edible Science: CB1 vs. CB2 Receptors
  13. [48:02] 11-Hydroxy-THC: Why Edibles Feel 10x Stronger
  14. [55:20] Fast-Acting Tech: How Nano-Emulsions Change Gummies
  15. [1:03:00] The "System Check": Explaining the Edible Hangover 1:10:00 - Mushroom Adaptogens & Long-Term Storage Science
  16. [1:19:15] The DuPont Connection: Cannabis History & Chemistry
  17. [1:22:30] Chat Q&A: Can You Make Nano-Emulsions at Home?
  18. [1:31:00] Kitchen Chemistry: Using Chickpea Water & Lecithin
  19. [1:42:00] Curing Science: Terpene Desiccation & Hashishene
  20. [1:50:10] Does It Wash? Why "Greasy" Strains are Disappearing
  21. [2:00:00] New Tech Recap: Puffco, Zooray & Clean Torch
  22. [2:10:45] Traveling with Cannabis: The Med Card Debate